Murdoch and Inspector Brackenreid are aboard the SS Keewatin after the owner, Clarence MacFarlane, receives what he believes is a threat. The Keewatin is about to depart from Toronto on its maiden voyage destined for Rochester, N.Y. and Murdoch thinks they should stay on board, especially after he sees that Julia is one of the invited guests. Their presence proves useful after MacFarlane's daughter Amy, who is engaged to her father's chief financial officer Owen Mathers, falls overboard and is nowhere to be found. As Murdoch investigates he finds there is a real threat against the Keewatin and the true facts behind Amy's disappearance.

Season five of Murdoch Mysteries opens in unfamiliar territory, as Detective William Murdoch (Yannick Bisson) leaves Toronto to try his luck while the Klondike Gold Rush in the Yukon winds down. Suspended for interfering in an investigation, on the run for surreptitiously freeing a murderer to make amends, and nursing a broken heart after Dr. Ogden's marriage to another man, he tries to escape his past, and his passion for detective work. Back in the city, newly promoted Chief Constable Giles (Nigel Bennett) makes it clear to Inspector Thomas Brackenreid (Thomas Craig), that he'll be keeping a very close eye on police matters. Meanwhile, Murdoch's beloved former associate, Dr. Julia Ogden (Hélène Joy), is now working alongside Acting Detective George Crabtree (Jonny Harris) and Dr. Emily Grace (Georgina Reilly), a feisty young protégé. In the remote north, Murdoch is pleased to discover that his fledgling prospecting career may garner great success, a small comfort after Julia's marriage to another man. But as he tries to rebuild his life, he finds himself drawn into the case of Mrs. Elizabeth Bryant (Jill Halfpenny), an innkeeper charged with murder. The plot thickens when writer Jack London (Aaron Ashmore) lends his insights, and Murdoch soon realizes that while he had hoped to leave his shattered heart and tattered career back in Toronto, his days as a detective are not behind him.

皮帕和托马斯搬进了他们梦寐以求的公寓，他们注意到他们的窗户正对着对面的公寓——邀请他们亲眼目睹街对面这对迷人夫妇的不稳定关系。但当他们试图以匿名方式介入他们的生活时，他们不知不觉地引发了一系列将导致灾难的事件。

In 1959, an alien experiment crashes to earth and infects a fraternity member. They freeze the body, but in the modern day, two geeks pledging a fraternity accidentally thaw the corpse, which proceeds to infect the campus with parasites that transform their hosts into killer zombies.

30年代，舞台演员Tyler Walker在他的恋人Myrna抛弃他跟别人结婚之后精神崩溃，整天在他的豪宅里跟一个打扮成Myrna模样的时装模型为伴，终于在一天晚上，Tyler上吊自杀。许多年后，深陷破产危机的Cates一家突然听说他们继承了Tyler的老房子，急于寻找片瓦遮身的Cates夫妇当即带着儿子Scott和女儿Robin前往。经历多年风雨，这所老房子变得残破不堪，而且还被暴躁成性的Silk为首的街头帮派占据。就在Cates一家忙于应付Silk及其党羽的时候，Tyler的鬼魂跑出来制造了更多混乱……

派屈克與父母到小島渡假，不料遭到不明生物攻擊，他的父母因而喪生！劫後餘生的派屈克因打擊過大而精神失常，心理學家為了幫助他療傷，特地帶他重回舊地，卻再度遭受擊…。後來才發現，因為石油公司在小島進行鑽探工作，破壞了自然生態，讓巨型蜥蜴科摩多產生攻擊性，他們能夠全身而退嗎？

当地球被敌对的外星势力攻击时，一个小镇的消防员和一个流氓的SETI科学家联手启动了唯一能够打败入侵者的技aaa。

The boisterous, arrogant professor Challenger, a reputed biologist and anthropologist, dares the London Zoological Society to mount an expedition to verify his spectacular claim, without physical proof, that his previous expedition to the Amazonian basin found live dinosaurs. Apart from him and his 'socialite' counterpart, professor Summerlee, it consists of experienced discoverer Lord Roxbury, the young reporter Ed Malone -who got publicly struck down with Challenger's umbrella at his arrival- and Jennifer Holmes, Malone's news agency's boss's daughter, essentially as conditions for putting up the money. In Brazil they are joined by Jennifer's brother David and local 'guide' Manuel Gomez. They soon discover the dinosaurs are real and dangerous, like giant spiders, but loose their helicopter and thus are desperate for a way down from the isolated plateau. They learn Roxbury knew about the fate of Burton White, an explorer whose diary they find, thus presume to be dead, in search of diamonds, and confirmation of the local tribe being the lethal guardians of the plateau's secrets, but also get surprising help...

In an uncharted future, two hardened souls meet and confront each other with the things they have done and what they have become.